Sheng-Xiang Lin Selected Research

3 (or 17)-beta-hydroxysteroid dehydrogenase

1/2017	17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation.
1/2017	Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1.
1/2017	Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.
12/2016	Genomic data on breast cancer transcript profile modulation by 17beta-hydroxysteroid dehydrogenase type 1 and 17-beta-estradiol.
6/2012	17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration.
1/2012	The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells.
4/2010	17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production.
12/2005	Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase.
11/2002	A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity.

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Sheng-Xiang Lin Research Topics

Disease

28	Breast Neoplasms (Breast Cancer) 11/2021 - 11/2002
19	Neoplasms (Cancer) 02/2022 - 02/2003
4	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 07/2004
1	Triple Negative Breast Neoplasms 02/2022
1	Virus Diseases (Viral Diseases) 05/2021
1	Severe Acute Respiratory Syndrome 06/2020
1	Carcinoma (Carcinomatosis) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Carcinogenesis 01/2020
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/2016
1	Endometriosis 08/2016
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2010
1	Pathologic Processes 07/2003

Drug/Important Bio-Agent (IBA)

19	EnzymesIBA 11/2021 - 07/2004
15	Estrogens (Estrogen)FDA Link 01/2020 - 11/2002
14	Hormones (Hormone)IBA 11/2021 - 07/2003
13	Estradiol (Delestrogen)FDA LinkGeneric 11/2021 - 12/2005
11	SteroidsIBA 01/2020 - 02/2003
9	3 (or 17)-beta-hydroxysteroid dehydrogenaseIBA 01/2017 - 11/2002
7	AndrogensIBA 01/2020 - 04/2003
7	Oxidoreductases (Dehydrogenase)IBA 12/2019 - 03/2009
6	Dihydrotestosterone (Androstanolone)IBA 11/2021 - 03/2009
6	Proteins (Proteins, Gene)FDA Link 05/2021 - 01/2012
5	Gonadal Steroid Hormones (Sex Hormones)IBA 10/2019 - 12/2009
4	SulfatasesIBA 10/2018 - 03/2009
3	Biological ProductsIBA 01/2017 - 06/2015
3	Estrogen ReceptorsIBA 01/2017 - 09/2013
3	Estrone FDA Link 01/2016 - 01/2012
3	Aromatase (CYP19)IBA 09/2015 - 03/2009
2	TransferasesIBA 05/2021 - 06/2020
2	Aromatase InhibitorsIBA 01/2020 - 09/2010
2	GlucocorticoidsIBA 01/2020 - 10/2019
2	Androgen Receptors (Androgen Receptor)IBA 01/2020 - 10/2019
2	Steryl-Sulfatase (Steroid Sulfatase)IBA 10/2018 - 09/2015
2	DNA (Deoxyribonucleic Acid)IBA 10/2018 - 01/2017
2	Endoplasmic Reticulum Chaperone BiPIBA 01/2017 - 01/2017
2	ProteomeIBA 01/2017 - 06/2012
2	Dehydroepiandrosterone (DHEA)IBA 01/2016 - 04/2003
1	Paclitaxel (Taxol)FDA LinkGeneric 02/2022
1	Hydroxysteroid DehydrogenasesIBA 11/2021
1	Peptide Hydrolases (Proteases)FDA Link 05/2021
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 05/2021
1	PapainIBA 05/2021
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Cyclin D1IBA 10/2018
1	Letrozole (Femara)FDA LinkGeneric 01/2017
1	Phenobarbital (Luminal)FDA Link 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	CollagenIBA 09/2015
1	Cathepsin BIBA 01/2012
1	HSP27 Heat-Shock ProteinsIBA 01/2012
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2012
1	Biomarkers (Surrogate Marker)IBA 01/2012
1	Cathepsin DIBA 01/2012
1	antineoplaston A10 (A 10)IBA 09/2010
1	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 01/2010
1	Ganciclovir (Cytovene)FDA LinkGeneric 01/2010
1	Foscarnet FDA LinkGeneric 01/2010
1	Testosterone (Sustanon)FDA Link 07/2004

Therapy/Procedure

10	Therapeutics 01/2020 - 07/2004
1	Castration 07/2004